Endocrine Abstracts

Drug-induced vasculitis or lupus-like syndromes can complicate the clinical course of PTU-treated patients. The clinical manifestations of four patients treated with PTU for Graves’ disease are presented.A 37-year-old woman was treated with PTU for six years. She had severe thyrotoxicosis, high fever and polyarthralgia. Elevated doses of PTU resulted in normalization of thyroid function, but the fever and arthralgia persisted even after steroid admi...

Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, in...